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Israel unleashed a punishing wave of strikes across the breadth of Iran on Sunday and Tehran hit back with fresh missile barrages, as both sides threatened more devastation in a conflict that appeared to be intensifying.
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After decades of enmity and a prolonged shadow war fought through proxies and covert operations, the latest conflict marks the first time the arch-enemies have traded fire with such intensity, triggering fears of a lengthy conflict that could engulf the entire Middle East.
Israeli authorities told citizens to head to shelters in advance of incoming missiles Sunday, while Iran said it would begin opening mosques, metro stations and schools to serve as makeshift refuges as Israel kept up its withering strikes.
Israel says its attacks have hit military and nuclear facilities, and killed top officers and atomic scientists, but a senior US official said Sunday that President Donald Trump had told Israel to back down from a plan to kill supreme leader Ayatollah Ali Khamenei.
Meanwhile, residential areas in both countries have suffered deadly strikes since the hostilities broke out two days ago, with Netanyahu on Sunday slamming Iran for allegedly targeting civilians.
"Iran will pay a very heavy price for the premeditated murder of civilians, women and children," he said during a visit to the site of a missile strike on a residential building in the coastal city of Bat Yam, near Tel Aviv.
The remarks came hours after overnight Iranian missile fire killed at least 10 people, according to authorities, pushing the death toll in Israel up to 13 since Iran began its retaliatory strikes Friday.
More missiles followed over the course of the day, with the Israeli military saying in the evening that search and rescue teams were dispatched to "several" sites that were hit.
Iranian state television, meanwhile, reported at least five people killed Sunday by an Israeli strike that hit a residential building in downtown Iran.
Colonel Reza Sayyad, a spokesman for Iran's armed forces, threatened a "devastating response" to Israel's attacks.
"Leave the occupied territories (Israel) because they will certainly no longer be habitable in the future," he warned in a televised address, adding shelters will "not guarantee security".
Iran's health ministry reported at least 224 people killed and more than 1,200 wounded in Israeli attacks since Friday.
On Sunday, Israel's military said its air force hit Mashhad airport in Iran's far east, making it the longest-range strike of the conflict, with the target "approximately 2,300 kilometres (1,430 miles) from Israel".
An Israeli strike also killed the intelligence chief of Iran's Revolutionary Guards, Mohammed Kazemi, along with two other officers, Iran's official IRNA news agency reported.
- 'I will not leave' -
A heavy cloud of smoke hung above Tehran after Israeli aircraft struck two fuel depots there. Local media also reported an Israeli strike on the police headquarters in the city centre.
"We haven't been able to sleep since Friday because of the terrible noise," said a Tehran resident who gave her name as Farzaneh.
"Today they hit a house in our alley, and we were very scared. So we decided to leave Tehran and head to the north of the country."
Some residents, however, were determined to stay put.
AFP images from the Israeli city of Haifa, meanwhile, also showed a column of smoke rising on Sunday evening following an Iranian missile barrage.
The military said rescue teams "have been dispatched to several hit sites in Israel", while the fire services reported rescuers heading to a building on the coast that sustained a "direct hit".
Earlier in the day, in Bat Yam, first responders wearing helmets and headlamps picked through a bombed-out building after a deadly overnight strike.
"There was an explosion and I thought the whole house had collapsed," said Bat Yam resident Shahar Ben Zion.
"It was a miracle we survived."
- 'Make a deal' -
Trump said Washington "had nothing to do" with Israel's bombing campaign.
But he also threatened to unleash "the full strength and might" of the US military if Iran attacked American interests, later urging the two foes to "make a deal".
A senior US official told AFP on Sunday that Trump had urged Israel to drop a plan to assassinate Khamenei.
"We found out that the Israelis had plans to hit Iran's supreme leader. President Trump was against it and we told the Israelis not to," said the US official, speaking on condition of anonymity.
Asked in an interview with Fox News whether regime change in Iran was one of the objectives of Israel's strikes, Netanyahu said that "it certainly could be the result, because the Iran regime is very weak".
Iran's top diplomat Abbas Araghchi maintained Tehran had "solid proof" that US forces had supported Israel in its attacks.
He also told a meeting of foreign diplomats that Iran's actions were a "response to aggression".
"If the aggression stops, naturally our responses will also stop," he added.
Iranian media reported Sunday that police had arrested two suspects over alleged links to Israel's Mossad spy agency.
Israel, in turn, said it had taken two individuals into custody over alleged links to Iranian intelligence.